Donghui Yang, Ph. D.
Tel: 82801559
Email: ydhui@bjmu.edu.cn
EDUCATION HISTORY
1998, 7 – 2000, 10 Postdoctoral Fellow with Prof. Shao-qing Cai
Peking University/School of Pharmaceutical Sciences
1995, 9 – 1998, 7 Ph.D. supervised by Prof. Yong-yan Wang & Prof. Lu-xue Wei
Beijing University of Chinese Medicine
1992, 9 – 1995, 7 M.S. supervised by Prof. Li-juan Liu
Heilongjiang University of Chinese Medicine
1988, 9 – 1992, 7 Bachelor of Sciences, School of Pharmaceutical Sciences,
Heilongjiang University of Chinese Medicine
PROFESSIONAL HISTORY
2000, 10 – now Associate Professor
School of Pharmaceutical Sciences, Peking University, China
2001, 1 – 2002, 1 Collaborator, Eisai Tsukuba Research Laboratories, Tsukuba, Japan
2008, 5 Visiting Scholar, Faculty of Pharmaceutical Science,
Nagasaki International University, Nagasaki, Japan
RESEARCH EXPERIENCE
2007 – Now
l Production of enterodiol and enterolactone from the defatted flaxseeds by intestinal bacteria
l The anti-depressive activities of enterodiol and secoisolariciresinol on ovariectomized mice
l Studies on the functional genes of active bacteria for deglycosylation and demethylation
l Metabolism of traditional Chinese medicines of Puerariae Lobatae Radix, Salviae Miltiorrhizae Radix et Rhizoma, and Chuanxiong Rhizoma.
2002– 2006
l The active substances of compound recipe of traditional Chinese medicine “Bu-yang-huan-wu Decoction” for treating ischemic cerebral stroke.
l Pharmacokinetic studies on the renal toxicity constituents of aristolochic acid-I and –II in Radix Aristolochiae and Muskone
l Studies on the chemical consistency of multi-original crude drugs: Herba Ephedrae Sinicae and Radix Stemonae
l 2000 – 2001
l Screening the active constituents in the pharmaceutical botanies originated from China
1998 – 2000
l The serum-chemistry of the chemical constituents of traditional Chinese medicine compound recipe “Bu-yang-huan-wu Decoction”
1995 – 1998
l Studies on the technology of new drug “Compound Cordyceps Capsule”
l Studies on the triterpenoid constituents from the roots of Scabiosaefolia fisch.
1992 – 1995
l Studies on the flavonoid constituents from Longpetal Globeflower
REPRESENTATIVE PUBLICATIONS
1. Yingfeng Wang, Zhikun Xu, Haiyan Yao, Baoshan Ku, Xiaoqing Ma, Chengzhi Wang, Shulin Liu, Shaoqing Cai, Donghui Yang*. The Anti-depressant effect of secoisolariciresinol, a lignan-type phytoestrogen constituent from flaxseed, on ovariectomized mice J. Nat. Med., 2012, DOI: 10.1007/s11418-012-0655-x.
2. Hao Hong, Hu-Biao Chen, Donghui Yang, Ming-Ying Shang, Xuan Wang, Shao-Qing Cai, Masayuki Mikage. Comparison of contents of five ephedrine alkaloids in three official origins of Ephedra Herb in China by high-performance liquid chromatography. J. Nat. Med., 2011, 65: 623-628.
3. Cheng-Zhi Wang, Xiao-Qing Ma, Donghui Yang* et al. Production of enterodiol from defatted flaxseeds through biotransformation by human intestinal bacteria. BMC Microbiology, 2010, 10: 115.
4. Xiao-Qing Ma, Wei-Feng Deng, Donghui Yang*, Guang-Xue Liu, Hao Hong, Kuang-Nam Paek, Shao-Qing Cai. HPLC fingerprinting and quantification of gentiopicroside and loganic acid in Gentianae Macrophyllae Radix crude drugs. J. Chin. Pharm. Sci., 2010, 19 (4): 243-250.
5. Pema Dolma, Donghui Yang*, Jie Yu, Xuan Wang, Shao-Qing Cai. Pharmacokinetic studies of aristolochic acid-I and –II in rats after intragastrical administration of Radix Aristolochiae and Muskone. J. Chin. Pharm. Sci., 2009, 18: 55-59.
6. Jun-Ping Hu, Donghui Yang, Wen-Han Lin, and Shao-Qing Cai, Alkaloids from the Roots of Stemona tuberosa. Helvetica Chimica Acta, 2009, 92, 2125-2133.
7. Lan-Lan Fan, Shu Zhu, Hu-Biao Chen, Donghui Yang, Shao-Qing Cai, Katsuko Komatsu. Molecular analysis of stemona plants in china based on sequences of four Chloroplast DNA regions. Biol. Pharm. Bull. 2009, 32 (8): 1439-1446.
8. Lan-Lan Fan, Shu Zhu, Hu-Biao Chen, Donghui Yang, Shao-Qing Cai, Katsuko Komatsu Identification of the Botanical Source of Stemonae Radix Based on PCR with Specific Primers and PCR-RFLP. Biol. Pharm. Bull. 2009, 32 (9): 1624-1627.
9. Bao-Song Cui, Xiao-Qing Ma, Donghui Yang*, Xue-Qiao Hu, Shao-Qing Cai. Purification method of rohitukine from the stem bark of Dysoxylum binectariferum. J. Chin. Pharm. Sci., 2008, 17: 153-157.
10.Donghui Yang, Shaoqing Cai, Hongyu Liu, Xinxin Guo, Changling Li, Mingying Shang, Xuan Wang, Yuying Zhao. On-line identification of the constituents of Buyang Huanwu decoction in pig serum using combined HPLC-DAD-MS techniques. J. Chromatography B, 2006, 831: 288-302.
11. Feng Xu, Yue Zhang, Shengyuan Xiao, Xiaowei Lu, Donghui Yang, Xiaoda Yang, Changling Li, Mingying Shang, Pengfei Tu, and Shaoqing Cai. Absorption and Metabolism of Astragali Radix Decoction: In silico, in vitro, and a case study in vivo. Drug Metabolism and Disposition, 2006, 34: 913-924.
